Melanocortin-3 receptors in the limbic system mediate feeding-related motivational responses during weight loss
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- 作者：Maria Mavrikaki1 ; 2 ; Clemence Girardet1 ; 2 ; Andras Kern1 ; Alicia Faruzzi Brantley3 ; 4 ; Courtney A. Miller1 ; 3 ; Heather Macarthur2 ; Daniel L. Marks5 ; Andrew A. Butler1 ; 2 ; Butleraa@slu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Melanocortins ; Melanocortin-3 receptors ; Dopamine ; Motivation ; Appetite ; Caloric restriction
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：5
- 期：7
- 页码：566-579
- 全文大小：2846 K
文摘
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Food-related motivational responses in mice increase with caloric restriction (CR).
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Melanocortin-3 receptors (MC3R) are required for food-related motivational responses.
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MC3Rs role in food-related motivational responses depends on metabolic condition.
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Mesolimbic MC3Rs increase food-related motivational responses during CR.