No association between bipolar affective disorder and a serotonin receptor (5-HT2A) polymorphism
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- 作者：Mahieu ; Brigitte ; Souery ; Daniel ; Lipp ; Olivier ; Mendelbaum ; Karin ; Verheyen ; Geert ; De Maertelaer ; Viviane ; et. al.
- 关键词：Candidate gene ; Serotonin transmission ; Allelic association
- 刊名：Psychiatry Research
- 出版年：1997
- 出版时间：May 5, 1997
- 年：1997
- 卷：70
- 期：2
- 页码：65-69
- 全文大小：399 K
文摘
The serotonergic system is implicated in the pathogenesis of affective disorders. In particular, the role of the postsynaptic 5-hydroxytryptamine (serotonin) type 2 receptor (5-HT2) has been documented by several studies. The 5-HT2A receptor gene located on chromosome 13 (13q14-21) can be considered a candidate gene for bipolar affective disorder (BPAD). We tested association between a 5-HT2A receptor DNA variant and BPAD using a case-control design. Eighty-three BPAD patients and 129 unrelated normal controls, carefully matched for sex and geographical origin, were studied. Allele and genotype frequencies as well as homo-heterozygote distribution at the 5-HT2A receptor polymorphism were compared between the two groups. No significant allelic or genotypic associations were observed. There was no significant difference for homo-heterozygote distribution between the two groups. These preliminary results may indicate that in our sample the 5-HT2 receptor polymorphism studied is unlikely to play a role in the genetic susceptibility to BPAD.