MAGP2 controls Notch via interactions with RGD binding integrins: Identification of a novel ECM-integrin-Notch signaling axis
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- 作者：Peter Defordb ; 1 ; Kasey Brownc ; Rae Lee Richardsc ; Aric Kingc ; Kristin Newburnc ; Katherine Westoverb ; Allan R. Albiga ; b ; AllanAlbig@boisestate.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：MAGP2 ; Microfibril associated glycoprotein 2 ; N1ICD ; Notch1 intracellular domain ; ECM ; Extracellular matrix ; HMEC ; Human microvascular endothelial cells.
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：341
- 期：1
- 页码：84-91
- 全文大小：1244 K
文摘
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A novel signaling mechanism between integrins and Notch is proposed.
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ECM molecules MAGP2 and EGFL7 control Notch via RGD binding integrins.
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Integrin–Notch signaling allows Notch to responds to cellular microenvironment.
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Integrin–Notch signaling helps explain pro- and anti-Notch activity of MAGP2.