Role of zinc as an antioxidant and anti-inflammatory to relieve cadmium oxidative stress induced testicular damage in rats

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• 作者：Samir Abd El-Monem Bashandy¹ ; Enayat Abdel Aziz Omara² ; Hossam Ebaid³ ; ⁴ ; Mohamed Mahmoud Amin¹ ; ^{mohamedmahmoud1983@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Mahmoud Sanad Soliman⁵
• 关键词：Zinc ; Cadmium ; Oxidative stress ; Immunohistochemistry ; Sperms ; Inflammatory markers
• 刊名：Asian Pacific Journal of Tropical Biomedicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：6
• 期：12
• 页码：1056-1064
• 全文大小：1137 K

文摘

To investigate the role of zinc in reducing the deleterious effects of cadmium on male gonads.

Methods

Rats were injected subcutaneously with CdCl₂ and ZnCl₂ at dose level of 2.2 mg/kg (1/40 of LD₅₀ of cadmium per day).

Results

The rats treated with cadmium exhibited a significant increase in levels of testicular malondialdehyde, tumor necrosis factor-alpha, nitrogen oxide and inducible nitrogen oxide synthase immunostaining reaction, as well as an elevation of blood hydroperoxide and follicle stimulating hormone. In addition, a significant decrease in testicular ascorbic acid, zinc, reduced glutathione, catalase, superoxide dismutase, sex organ weight, plasma testosterone and luteinizing hormone were observed in the cadmium group. Sperm motility and count were decreased with cadmium treatment, while sperm abnormalities elevated significantly. Zinc treatment was found to mitigate the toxic effects of cadmium on oxidative stress, spermatogenesis, sex hormones, and inflammatory markers. Rats injected with cadmium showed intense histopathological changes. Zinc manifested protective role and markedly reduced tissues damage induced by cadmium.

Conclusions

The protective effect of zinc can be attributed to its antioxidant and anti-inflammatory properties.