The first ferrocene analogues of muramyldipeptide

详细信息    查看全文

• 作者：Lidija Bariš ; i&#x107 ; ^a ; ^{lbaris@pbf.hr} ; Maja Roš ; &#x10d ; i&#x107 ; ^b ; Monika Kova&#x10d ; evi&#x107 ; ^a ; Mojca &#x10c ; aki&#x107 ; Semen&#x10d ; i&#x107 ; ^a ; Š ; tefica Horvat^b ; Vladimir Rapi&#x107 ; ^a
• 关键词：Ferrocene ; 1′ ; -Aminoferrocene-1-carboxylic acid (Fca) ; Muramyldipeptide (MDP) ; β ; -Turn ; Intramolecular hydrogen bond (IHB)
• 刊名：Carbohydrate Research
• 出版年：2011
• 出版时间：1 April 2011
• 年：2011
• 卷：346
• 期：5
• 页码：678-684
• 全文大小：575 K

文摘

The two structurally interesting bioorganometallic analogues of muramyldipeptide (MDP) with potential immunomodulatory activity were synthesized starting from the O-protected N-acetylmuramic acid (MurNAc), l- or d-Ala and 1′-aminoferrocene-1-carboxylic acid (Fca). They were fully characterized by IR, ¹H NMR, ¹³C NMR and CD spectroscopy as well as by FD mass spectrometry.