Significance of CD66c expression in childhood acute lymphoblastic leukemia
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- 作者：Nobutaka Kiyokawa ; Kazutoshi Iijima ; Osamu Tomita ; Masashi Miharu ; Daisuke Hasegawa ; Kenichiro Kobayashi ; Hajime Okita ; Michiko Kajiwara ; Hiroyuki Shimada ; Takeshi Inukai ; Atsushi Makimoto ; Takashi Fukushima ; Toru Nanmoku ; Katsuyoshi Koh ; Atsushi Manabe ; Akira Kikuchi ; Kanji Sugita ; Junichiro Fujimoto ; Yasuhide Hayashi ; Akira Ohara ; et al.
- 关键词：CD66c ; Acute lymphoblastic leukemia ; CRLF2 ; Flow cytometry ; Genetic abnormality
- 刊名：Leukemia Research
- 出版年：January, 2014
- 年：2014
- 卷：38
- 期：1
- 页码：42-48
- 全文大小：1392 K
文摘
Upon analyzing 696 childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, we identified the characteristics of CD66c expression. In addition to the confirmation of strong correlation with BCR-ABL positivity and hyperdiploid, we further observed that CD66c is frequently expressed in CRLF2-positive (11/15, p < 0.01 against chimeric gene-negative) as well as hypodiploid cases (3/4), whereas it is never expressed in ETV6-RUNX1, MLL-AF4, MLL-AF9, MLL-ENL, and E2A-PBX1-positive cases. Although the expression of CD66c itself is not directly linked to the prognosis, the accompanying genetic abnormalities are important prognostic factors for BCP-ALL, indicating the importance of CD66c expression in the initial diagnosis of BCP-ALL.