The identification of risk factors for venous thromboembolism in gastrointestinal oncologic surgery

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• 作者：Geoffrey Bellini ; MD^a ; ^{geoff.bellini@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Annabelle Teng ; MD^a ; Nisha Kotecha ; MD^b ; Elie Sutton ; MD^a ; Chun Kevin Yang ; MD^a ; Michael Passeri ; MD^a ; David Y. Lee ; MD^c ; Keith Rose ; MD^b
• 关键词：VTE ; Venous thromboembolism ; ACS-NSQIP ; Malignancy ; Gastrointestinal
• 刊名：Journal of Surgical Research
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：205
• 期：2
• 页码：279-285
• 全文大小：250 K

文摘

The aim of this study was to examine the incidence and factors associated with occurrence of venous thromboembolism (VTE) in patients undergoing major gastrointestinal (GI) surgery for malignancy.

Methods

The American College of Surgeon's National Surgical Quality Improvement Program, Participant User File database was queried from 2005 to 2012 to study major GI operations performed for cancer. Predictors of VTE and their relation to survival were studied.

Results

In 79,300 patients, the incidence of deep venous thrombosis was 1.7%, and pulmonary embolism was 0.9% during the 30-d postoperative period. The highest rate of VTE occurred after esophagectomy (5.9%) followed by pancreatectomy (3.2%), hepatectomy (3.2%), gastrectomy (2.5%), enterectomy (2.3%), colectomy, and proctectomy (2.0%). On multivariate analysis, disseminated cancer, age ≥ 80 y, body mass index > 35 kg/m², functional status, post operative sepsis, pulmonary dysfunction, and longer operative time were associated with occurrence of VTE. Occurrence of VTE was associated with mortality on multivariate analysis (odds ratio 2.4, 95% confidence interval 2.0-3.0, P < 0.001).

Conclusions

Absolute incidence of VTE after major GI surgery is low but is associated with significant mortality and postoperative complications. Disseminated cancer, post operative sepsis, longer operative time, and increased body mass index >35 kg/m² further increased the risk of VTE in patients undergoing surgery for malignancy. Surveillance strategies should be implemented for those cancer patients who have multiple risk factors for VTE.