In vitro characterization and endocrine regulation of cholesterol and phospholipid transport in the mammary gland

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• 作者：Corneille Edgar Ontsouka^a ; ^b ; Xiao Huang^a ; ^b ; Eldar Aliyev^a ; Christiane Albrecht^a ; ^b ; ^{christiane.albrecht@ibmm.unibe.ch}
• 关键词：Cholesterol ; Phospholipid ; Transport ; Regulation ; Hormone ; Efflux ; Apolipoprotein A-1
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：35-45
• 全文大小：1895 K
• 卷排序：439

文摘

MAC-T cells are a suitable model for lipid transport studies in the mammary gland. Cholesterol and phospholipid transport in MEC is mediated by apoA-1/ABCA1 and ABCG1/HDL dependent pathways. ApoA-1/ABCA1 activity in MEC causes activation of intracellular signaling cascades (JAK-2, MAPK). The transported cholesterol stems mainly from the plasma membrane. Insulin plays an important role in regulating lipid transport in MEC.