Changes in mammary histology and transcriptome profiles by low-dose exposure to environmental phenols at critical windows of development

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• 作者：Kalpana Gopalakrishnan^a ; Susan L. Teitelbaum^a ; Luca Lambertini^a ; James Wetmur^b ; Fabiana Manservisi^c ; Laura Falcioni^c ; Simona Panzacchi^c ; Fiorella Belpoggi^c ; Jia Chen^a ; ^d ; ^e ; ^f ; ^{jia.chen@mssm.edu}
• 关键词：Paraben ; Triclosan ; Mammary Transcriptome and Histology ; Breast cancer ; Windows of susceptibility
• 刊名：Environmental Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：152
• 期：Complete
• 页码：233-243
• 全文大小：1404 K
• 卷排序：152

文摘

Human-level exposure to environmental phenols modifies mammary transcriptome. Human-level exposure to environmental phenols induces changes in mammary histology. Exposure-induced changes in mammary glands are developmental window specific. Chemical-modified genes are enriched with human breast cancer gene signatures.