Mannosidase IA is in Quality Control Vesicles and Participates in Glycoprotein Targeting to ERAD
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- 作者：Navit Ogen-Shtern&dagger ; ; Edward Avezov&dagger ; ; Marina Shenkman ; Ron Benyair ; Gerardo Z. Lederkremer ; gerardo@post.tau.ac.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：ER ; endoplasmic reticulum ; ERAD ; ER-associated degradation ; ERManI ; ER α1 ; 2 mannosidase I ; EDEMs ; ER-degradation enhancing mannosidase-like proteins ; CNX ; calnexin ; ManIA ; class I α1 ; 2 mannosidase IA ; QCVs ; quality control vesicles ; NHK ; α1-antitrypsin variant null Hong Kong ; ERQC ; ER-derived quality control compartment ; LC3 ; microtubule-associated protein1 Light chain 3 ; BFA ; brefeldin A ; Bz ; bortezomib ; IgG ; immunoglobulin G
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：14 August 2016
- 年：2016
- 卷：428
- 期：16
- 页码：3194-3205
- 全文大小：1393 K
文摘
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The removal of alpha 1,2 mannose residues from its N-glycans targets a misfolded glycoprotein to ERAD.
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We found mannosidase IA implicated in this process in addition to ER mannosidase I and the EDEMs.
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Surprisingly, mannosidase IA is not located in the Golgi but resides in QCVs.
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This adds another level of apparent redundancy in this fateful step of glycoprotein quality control.