Polarity Reversal by Centrosome Repositioning Primes Cell Scattering during Epithelial-to-Mesenchymal Transition

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• 作者：Mithila Burute¹ ; ² ; ³ ; Magali Prioux² ; Guillaume Blin⁴ ; Sandrine Truchet⁵ ; Gaë ; lle Letort² ; Qingzong Tseng² ; Thomas Bessy¹ ; Sally Lowell⁴ ; Joanne Young³ ; Odile Filhol⁶ ; Manuel Thé ; ry¹ ; ² ; ⁷ ; ^{manuel.thery@cea.fr}
• 关键词：EMT ; polarity ; cytoskeleton ; centrosome ; microtubule ; stathmin ; migration ; micropatterning ; intercellular junctions
• 刊名：Developmental Cell
• 出版年：2017
• 出版时间：23 January 2017
• 年：2017
• 卷：40
• 期：2
• 页码：168-184
• 全文大小：6019 K
• 卷排序：40

文摘

Nucleus-centrosome axis orientation is reverted during EMT in vivo and in vitro Centrosome relocates from epithelial cell periphery to mesenchymal cell center Centrosome position depends on the level of polymerized tubulin Polarity reversal promotes disengagement and scattering of mesenchymal cells