The MAOA, COMT, MTHFR and ESR1 gene polymorphisms are associated with the risk of depression in menopausal women
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- 作者：Agata Ró ; życkaa ; 1 ; arozycka@ump.edu.pl" class="auth_mail" title="E-mail the corresponding author ; Radosław Słopieńb ; 1 ; Agnieszka Słopieńc ; Jolanta Dorszewskad ; Agnieszka Seremak-Mrozikiewicze ; f ; Margarita Lianeria ; Małgorzata Maciukiewiczg ; Alina Warenik-Szymankiewiczb ; Teresa Grzelakh ; Grażyna Kurzawińskae ; Krzysztof Drewse ; Andrzej Klejewskii ; Paweł P. Jagodzińskia
- 关键词：MAOA ; COMT ; MTHFR ; ESR1 ; Gene polymorphism ; Menopausal depression
- 刊名：Maturitas
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：84
- 期：Complete
- 页码：42-54
- 全文大小：958 K
文摘
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We found associations between the MAOA c.1460C > T, COMT c.472G > A, MTHFR c.677C > T and ESR1 454-351 A > G polymorphisms to mild and moderate depressive symptoms in menopausal women.
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No significant differences were observed in either the frequencies of the genotypes or alleles between the patients and the controls in the polymorphic variants of the 5HTR2A, 5HTR1B, 5HTR2C, TPH1, TPH2, COMT, NET, GABRB1, MTR and MTHFD1 genes.
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This is an innovative study presenting a new research area and suggesting a direction for further investigation in genetics of depression in women during midlife.