Synthesis and evaluation of novel isoxazolyl chalcones as potential anticancer agents
详细信息 查看全文
- 作者：Maosheng Wana ; 1 ; Linyan Xub ; 1 ; Li Huac ; Ailing Lic ; Shuqing Lic ; Wenjing Lua ; Yue Panga ; Chengbo Caoa ; cbcao@sdu.edu.cn" class="auth_mail ; Xiangguo Liub ; ; Peifu Jiaod ;
- 关键词：Isoxazolyl chalcones ; Synthesis ; Human non-small cell lung cancer cells ; Apoptosis ; Death receptor 5
- 刊名：Bioorganic Chemistry
- 出版年：June 2014
- 年：2014
- 卷：54
- 期：Complete
- 页码：38-43
- 全文大小：997 K
文摘
- •
Nine novel isoxazolyl chalcones were synthesized.
- •
They were evaluated for anticancer activity in vitro.
- •
Compounds bearing EWG at the 2-position in Ar group exhibited strong anticancer activities.
- •
Compounds 5f–i induced apoptosis by DR5 mediated extrinsic pathway in A549 cells.