Inhibition of the p38-MAPK signaling pathway suppresses the apoptosis and expression of proinflammatory cytokines in human osteoarthritis chondrocytes

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• 作者：He-Yan Sun ; Kong-Zu Hu ; Zong-Sheng Yin ; ^{yinzongsheng@sina.com}
• 关键词：Py38-MAPK signaling pathway ; Osteoarthritis ; Human chondrocytes ; Apoptosis ; Proinflammatory cytokines
• 刊名：Cytokine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：90
• 期：Complete
• 页码：135-143
• 全文大小：2297 K
• 卷排序：90

文摘

Inhibition of p38-MAPK pathway suppresses cell apoptosis of OA chondrocytes. Inhibition of p38-MAPK pathway decreases cytokine expression in OA. p38-MAPK pathway inhibitors reverse the effects of IL-1β. p38-MAPK pathway-related proteins overexpressed in OA chondrocytes. IL-1, IL-6, TNF-α overexpressed in OA chondrocytes.