New titanocene derivatives with high antiproliferative activity against breast cancer cells
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- 作者：Carmela Saturnino ; Esther Sirignano ; Antonio Botta ; Maria Stefania Sinicropi ; Anna Caruso ; Assunta Pisano ; Rosamaria Lappano ; Marcello Maggiolini ; Pasquale Longo
- 关键词：Metal-based anticancer drugs ; Titanocene compounds ; Breast cancer cells
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：1 January, 2014
- 年：2014
- 卷：24
- 期：1
- 页码：136-140
- 全文大小：685 K
文摘
The synthesis and characterization of some new titanocene-complexes, having a ethenyl-phenoxide or a benzyl group as substituents of the cyclopentadienyl rings, are reported. The synthesized compounds have been evaluated for their cytotoxic potential against two human breast cancer cell lines, that is: MCF7 and SkBr3. Most of these compounds have shown significant cytotoxic effects, compared to cisplatin, in MTT-based cell tests.