Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders
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- 作者：Kristen J. Brennand1 ; 23 ; M. Carol Marchetto2 ; 23 ; Nissim Benvenisty3 ; Oliver Brü ; stle4 ; Allison Ebert5 ; Juan Carlos Izpisua Belmonte6 ; Ajamete Kaykas7 ; Madeline A. Lancaster8 ; Frederick J. Livesey9 ; Michael J. McConnell10 ; Ronald D. McKay11 ; Eric M. Morrow12 ; Alysson R. Muotri13 ; David M. Panchision14 ; Lee L. Rubin15 ; Akira Sawa16 ; Frank Soldner17 ; Hongjun Song18 ; Lorenz Studer19 ; Sally Temple20 ; Flora M. Vaccarino21 ; Jun Wu6 ; Pierre Vanderhaeghen22 ; Fred H. Gage2 ; fgage@salk.edu" class="auth_mail" title="E-mail the corresponding author ; Rudolf Jaenisch17 ; jaenisch@wi.mit.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2015
- 出版时间：8 December 2015
- 年：2015
- 卷：5
- 期：6
- 页码：933-945
- 全文大小：2387 K
文摘
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A key limitation of the field is difficulty in accurately defining cell state
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Next step will be building complexity by achieving network and circuit structures
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Epigenetic factors and somatic mosaicism in iPS cells may contribute to disease
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A critical advance will be improving scalability and reproducibility of assays