Repurposing the anticancer drug mitomycin C for the treatment of persistent Acinetobacter baumannii infections

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• 作者：Martha Yumiko Cruz-Muñ ; iz^a ; Luis Esau Ló ; pez-Jacome^a ; ^b ; Melissa Herná ; ndez-Durá ; n^b ; Rafael Franco-Cendejas^b ; Paula Licona-Limó ; n^c ; Jose Luis Ramos-Balderas^c ; Mariano Martiné ; z-Vá ; zquez^d ; Javier A. Belmont-Dí ; az^e ; Thomas K. Wood^f ; Rodolfo Garcí ; a-Contreras^a ; ^{rgarc@bq.unam.mx}
• 关键词：Drug repurposing ; Antibiotic resistance ; Anticancer drugs
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：1
• 页码：88-92
• 全文大小：388 K
• 卷排序：49

文摘

Acinetobacter baumannii is a multidrug resistant emergent pathogen responsible for nosocomial infections. The anticancer drug mitomycin C (MMC) is able to kill A. baumannii exponential-phase, stationary-phase and biofilm cells. MMC rescues Galleria mellonella against lethal doses of reference and clinical multidrug resistant A. baumannii strains.