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The Molecular Taxonomy of Primary Prostate Cancer
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文摘
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Comprehensive molecular analysis of 333 primary prostate carcinomas

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Seven subtypes defined by ETS fusions or mutations in SPOP, FOXA1, and IDH1

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Substantial epigenetic heterogeneity, including a hypermethylated IDH1 mutant subset

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Presumed actionable lesions in the PI3K, MAPK, and DNA repair pathways

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