Role of MAPK p38 in the cellular responses to pore-forming toxins

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• 作者：Helena Porta¹ ; ^a ; Angeles Cancino-Rodezno¹ ; ^a ; Mario Sober&#xf3 ; n^a ; Alejandra Bravo ; ^a ; ^{bravo@ibt.unam.mx}
• 关键词：MAPK p38 ; Pore-forming toxins ; Cry toxin ; Intracellular responses
• 刊名：Peptides
• 出版年：2011
• 出版时间：March 2011
• 年：2011
• 卷：32
• 期：3
• 页码：601-606
• 全文大小：303 K

文摘

Understanding the mechanism of action of pore-forming toxins (PFTs) produced by different bacteria, as well as the host responses to toxin action, would provide ways to deal with these pathogenic bacteria. PFTs affect the permeability of target cells by forming pores in their plasma membrane. Target organisms may overcome these effects by triggering intracellular responses that have evolved as defense mechanisms to PFT. Among them it is well documented that stress-activated protein kinases, and specially MAPK p38 pathway, play a crucial role triggering defense responses to several PFTs in different eukaryotic cells. In this review we describe different intracellular effects induced by PFTs in eukaryotic cells and highlight diverse responses activated by p38 pathway.