Design and synthesis of selective inhibitors of Placental Alkaline Phosphatase

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• 作者：Marion Lanier ; Eduard Sergienko ; Ana Maria Simã ; o ; Ying Su ; Thomas Chung ; José ; Luis Millá ; n ; John R. Cashman
• 关键词：Enzyme inhibitor ; Placental Alkaline Phosphatase ; Cancer ; Oncodevelopmental
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2010
• 出版时间：15 January 2010
• 年：2010
• 卷：18
• 期：2
• 页码：573-579
• 全文大小：2469 K

文摘

Placental Alkaline Phosphatase (PLAP) is a tissue-restricted isozyme of the Alkaline Phosphatase (AP) superfamily. PLAP is an oncodevelopmental enzyme expressed during pregnancy and in a variety of human cancers, but its biological function remains unknown. We report here a series of catechol compounds with great affinity for the PLAP isozyme and significant selectivity over other members of the AP superfamily. These selective PLAP inhibitors will provide small molecule probes for the study of the pathophysiological role of PLAP.