Computational proteomics pitfalls and challenges: HavanaBioinfo 2012 Workshop report

详细信息    查看全文

• 作者：Yasset Perez-Riverol ; Henning Hermjakob ; Oliver Kohlbacher ; Lennart Martens ; David Creasy ; J¨¹rgen Cox ; Felipe Leprevost ; Baozhen Paul Shan ; Violeta I. P¨¦rez-Nueno ; Michal Blazejczyk ; Marco Punta ; Klemens Vierlinger ; Pedro A. Valiente ; Kalet Leon ; Glay Chinea ; Osmany Guirola ; Ricardo Bringas ; Gleysin Cabrera ; Gerardo Guillen ; Gabriel Padron ; et al.
• 关键词：Bioinformatics workshop ; Mass spectrometry ; Course ; Protein identification ; Database searching ; Proteomic repositories
• 刊名：Journal of Proteomics
• 出版年：2013
• 出版时间：11 July, 2013
• 年：2013
• 卷：87
• 期：Complete
• 页码：134-138
• 全文大小：258 K

文摘

The workshop ¡°Bioinformatics for Biotechnology Applications (HavanaBioinfo 2012)¡±, held December 8-11, 2012 in Havana, aimed at exploring new bioinformatics tools and approaches for large-scale proteomics, genomics and chemoinformatics. Major conclusions of the workshop include the following: (i) development of new applications and bioinformatics tools for proteomic repository analysis is crucial; current proteomic repositories contain enough data (spectra/identifications) that can be used to increase the annotations in protein databases and to generate new tools for protein identification; (ii) spectral libraries, de novo sequencing and database search tools should be combined to increase the number of protein identifications; (iii) protein probabilities and FDR are not yet sufficiently mature; (iv) computational proteomics software needs to become more intuitive; and at the same time appropriate education and training should be provided to help in the efficient exchange of knowledge between mass spectrometrists and experimental biologists and bioinformaticians in order to increase their bioinformatics background, especially statistics knowledge.