Respiratory viruses and influenza-like illness: Epidemiology and outcomes in children aged 6 months to 10 years in a multi-country population sample

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• 作者：Sylvia Taylor^a ; ^o ; ^{sylvia.m.taylor@GSK.com} ; Pio Lopez^b ; Lily Weckx^c ; Charissa Borja-Tabora^d ; Rolando Ulloa-Gutierrez^e ; Eduardo Lazcano-Ponce^f ; Angkool Kerdpanich^g ; Miguel Angel Rodriguez Weber^h ; Abiel Mascare&ntilde ; as de Los Santosⁱ ; Juan-Carlos Tinoco^j ; Marco Aurelio P. Safadi^k ; Fong Seng Lim^l ; Marcela Hernandez-de Mezerville^e ; Idis Faingezicht^e ; Aurelio Cruz-Valdez^f ; Yang Feng^a ; Ping Li^m ; Serge Durviaux^a ; Gerco Haars^a ; Sumita Roy-Ghanta^m ; David W. Vaughn^m ; Terry Nolanⁿ ; ^o
• 关键词：Active surveillance ; Influenza-like illness ; Healthy children ; Respiratory viruses ; Prevalence ; Incidence
• 刊名：Journal of Infection
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：74
• 期：1
• 页码：29-41
• 全文大小：1069 K
• 卷排序：74

文摘

Better population data on respiratory viruses in children in tropical and southern hemisphere countries is needed.MethodsThe epidemiology of respiratory viruses among healthy children (6 months to <10 years) with influenza-like illness (ILI) was determined in a population sample derived from an influenza vaccine trial (NCT01051661) in 17 centers in eight countries (Australia, South East Asia and Latin America). Active surveillance for ILI was conducted for approximately 1 year (between February 2010 and August 2011), with PCR analysis of nasal and throat swabs.Results6266 children were included, of whom 2421 experienced 3717 ILI episodes. Rhinovirus/enterovirus had the highest prevalence (41.5%), followed by influenza (15.8%), adenovirus (9.8%), parainfluenza and respiratory syncytial virus (RSV) (both 9.7%), coronavirus (5.6%), human metapneumovirus (5.5%) and human bocavirus (HBov) (2.0%). Corresponding incidence per 100 person-years was 29.78, 11.34, 7.03, 6.96, 6.94, 4.00, 3.98 and 1.41. Except for influenza, respiratory virus prevalence declined with age. The incidence of medically-attended ILI associated with viral infection ranged from 1.03 (HBov) to 23.69 (rhinovirus/enterovirus). The percentage of children missing school or daycare ranged from 21.4% (HBov) to 52.1% (influenza).ConclusionsActive surveillance of healthy children provided evidence of respiratory illness burden associated with several viruses, with a substantial burden in older children.