Essential Roles of Bone Morphogenetic Protein-1 and Mammalian Tolloid-like 1 in Postnatal Root Dentin Formation

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• 作者：Jun Wang ; DDS ; PhD^&lowast ; ; ^&dagger ; ; Alison M. Muir ; PhD^&Dagger ; ; Yinshi Ren ; PhD^&lowast ; ; Dawiyat Massoudi ; PhD^&Dagger ; ; Daniel S. Greenspan ; PhD^&Dagger ; ; Jian Q. Feng ; PhD^&lowast ; ; ^{JFeng@tamhsc.edu}
• 关键词：Bmp1 ; dentin ; odontoblast ; Tll1 ; tooth root
• 刊名：Journal of Endodontics
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：43
• 期：1
• 页码：109-115
• 全文大小：3868 K
• 卷排序：43

文摘

Deletions of Bmp1/Tll1 result in short tooth roots and severe defects in dentin mineralization. Bmp1/Tll1 null mice display an unexpected delayed tooth eruption. Bmp1/Tll1 null mice show collagen accumulations but a reduction in non-collagenous proteins. This study provides novel evidence that Bmp1/Tll1 is required for maintenance of ECM homeostasis.