RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells
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- 作者：Ulrike Hö ; ckendorf1 ; 12 ; Monica Yabal1 ; 12 ; Tobias Herold2 ; Enkhtsetseg Munkhbaatar1 ; Stephanie Rott1 ; Stefanie Jilg1 ; Johanna Kauschinger1 ; Giovanni Magnani3 ; Florian Reisinger4 ; Michael Heuser5 ; Hans Kreipe6 ; Karl Sotlar7 ; Thomas Engleitner8 ; 9 ; Roland Rad8 ; 9 ; Wilko Weichert9 ; 10 ; Christian Peschel1 ; 9 ; Jü ; rgen Ruland3 ; 9 ; Mathias Heikenwalder4 ; 11 ; Karsten Spiekermann2 ; 9 ; Julia Slotta-Huspenina10 ; Olaf Groß ; 3 ; Philipp J. Jost1 ; 9 ; philipp.jost@tum.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：11 July 2016
- 年：2016
- 卷：30
- 期：1
- 页码：75-91
- 全文大小：7367 K
文摘
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RIPK3 suppresses HSPC transformation by promoting cell death and differentiation
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Cell death in leukemia-initiating cells is driven by TNFR-driven RIPK3 activation
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RIPK3 promotes differentiation of LIC by activating the inflammasome
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RIPK3 expression is reduced in several subtypes of primary de novo AML