LINE(1)s of Evidence in HBV-Driven Liver Cancer

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• 作者：Mathias Heikenwalder¹ ; ^{heikenwaelder@helmholtz-muenchen.de" class="auth_mail} ; Ulrike Protzer¹ ; ^{protzer@tum.de" class="auth_mail}
• 刊名：Cell Host Microbe
• 出版年：12 March, 2014
• 年：2014
• 卷：15
• 期：3
• 页码：249-250
• 全文大小：242 K

文摘

Hepatitis B virus (HBV) integration in hepatocellular carcinoma (HCC) is a poorly understood event. In a recent Cancer Cell paper, describe a HBV-human fusion transcript (HBx-LINE1) that functions as a lncRNA, influences the epithelial-mesenchymal transition, and correlates with reduced patient survival and tumor formation in mice.