Nocathiacin I analogues: synthesis, in vitro and in vivo biological activity of novel semi-synthetic thiazolyl peptide antibiotics

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• 作者：Naidu ; B. Narasimhulu ; Sorenson ; Margaret E. ; Zhang ; Yunhui ; Kim ; Oak K. ; Matiskella ; John D. ; et. al.
• 关键词：Nocathiacins ; Conjugate addition ; Frozen water ; Antibacterial activity
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2004
• 出版时间：November 15, 2004
• 年：2004
• 卷：14
• 期：22
• 页码：5573-5577
• 全文大小：276 K

文摘

Several nocathiacin I analogues (4aaa35) were synthesized and evaluated for their antibacterial activity. Most of these semi-synthetic analogues retained very good in vitro and in vivo antibacterial activity of 1.