Human Herpesvirus 6 Infection Following Haploidentical Transplantation: Immune Recovery and Outcome
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- 作者：Raffaella Greco1 ; Lara Crucitti2 ; Maddalena Noviello3 ; Sara Racca4 ; Daniele Mannina1 ; Alessandra Forcina1 ; Francesca Lorentino1 ; Veronica Valtolina3 ; Serena Rolla4 ; Roee Dvir4 ; Mara Morelli1 ; Fabio Giglio1 ; Maria Chiara Barbanti1 ; Maria Teresa Lupo Stanghellini1 ; Chiara Oltolini5 ; Luca Vago1 ; 6 ; Paolo Scarpellini5 ; Andrea Assanelli1 ; Matteo G. Carrabba1 ; Sarah Marktel1 ; Massimo Bernardi1 ; Consuelo Corti1 ; Massimo Clementi4 ; 7 ; Jacopo Peccatori1 ; Chiara Bonini3 ; Fabio Ciceri1 ; 7 ; ciceri.fabio@hsr.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Human herpesvirus 6 ; Allogeneic hematopoietic stem cell transplantation ; T cell immune reconstitution
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：22
- 期：12
- 页码：2250-2255
- 全文大小：722 K
文摘
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This work is a retrospective analysis of 54 adult patients, positive for human herpesvirus 6 (HHV-6) after allogeneic stem cell transplantation.
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Viral encephalitis was reported for 10 patients.
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Mortality rate was relatively high in this population (1-year overall survival [OS], 38%).
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Better OS was associated with CD3+ cell count ≥200/µL at the time of HHV-6 reactivation.
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Prospective studies with characterization of HHV-6 immune responses are warranted.