Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex

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• 作者：Jessica J. Howell¹ ; ⁴ ; Kristina Hellberg² ; ⁴ ; Marc Turner¹ ; George Talbott¹ ; Matthew J. Kolar³ ; Debbie S. Ross² ; Gerta Hoxhaj¹ ; Alan Saghatelian³ ; Reuben J. Shaw² ; ^{shaw@salk.edu} ; Brendan D. Manning¹ ; ⁵ ; ^{bmanning@hsph.harvard.edu}
• 关键词：metformin ; AMPK ; tuberous sclerosis complex ; TSC1 ; TSC2 ; mTOR ; mTORC1 ; liver ; hepatocytes ; protein synthesis
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：463-471
• 全文大小：3087 K
• 卷排序：25

文摘

Metformin strongly inhibits mTORC1 in mouse liver and mouse and human hepatocytes AMPK is required for inhibition of hepatic mTORC1 signaling with low-dose metformin The TSC complex is required for inhibition of hepatic mTORC1 with low-dose metformin Metformin attenuates protein synthesis in hepatocytes through the TSC complex