Particulate matter cytotoxicity in cultured SH-SY5Y cells is modulated by simvastatin: Toxicological assessment for oxidative damage

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• 作者：S.A. Ferraro^a ; ^{sebaferraro@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; F. Astort^a ; J.S. Yakisich^b ; D.R. Tasat^a ; ^c
• 关键词：SH-SY5Y cells ; Simvastatin ; Cytotoxicity ; ROFA ; Ambient particle ; Air pollution
• 刊名：Neurotoxicology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：53
• 期：Complete
• 页码：108-114
• 全文大小：1150 K

文摘

<dl class="listitem" id="list_lis0005"><dt class="label">•dt><dd>

d="par0005">There is a correlation between environmental particulate matter and health effects.

dd><dt class="label">•dt><dd>

d="par0010">We studied in vitro simvastatin&rsquo;s potential protective effect on ROFA cytotoxicity.

dd><dt class="label">•dt><dd>

d="par0015">ROFA decreased cell viability, increased ROS generation, apoptosis and senescence.

dd><dt class="label">•dt><dd>

d="par0020">Pretreatment with simvastatin attenuated the adverse effects observed.

dd><dt class="label">•dt><dd>

d="par0025">Simvastatin may provide protection against particulate matter-induced neurotoxicity.

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