Transcatheter Aortic Valve Replacement is Associated with Comparable Clinical Outcomes to Open Aortic Valve Surgery but with a Reduced Length of In-Patient Hospital Stay: A Systematic Review and Meta-Analysis of Randomised Trials

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• 作者：Matthew Burrage ; MBBS^a ; ^b ; Peter Moore ; MBBS ; FRACP^a ; ^b ; Chris Cole ; MBBS ; FRACS^a ; ^b ; Stephen Cox ; MBBS ; FRACP^a ; ^b ; ^c ; Wing Chi Lo ; MBBS ; PhD ; FRACS^a ; ^b ; Anthony Rafter ; BPharm ; MBBS ; FRACP^b ; ^c ; Bruce Garlick ; MBBS ; FRACS^b ; ^c ; Paul Garrahy ; MBBS ; FRACP^a ; ^b ; Julie Mundy ; MBBS ; MBA ; FRACS^a ; ^b ; Anthony Camuglia ; MBBS ; FRACP^a ; ^b ; ^c ; ^{ACamuglia@heartcarepartners.com.au}
• 关键词：Transcatheter aortic valve replacement (TAVR) ; Surgical aortic valve replacement (SAVR) ; Aortic stenosis
• 刊名：Heart, Lung and Circulation
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：26
• 期：3
• 页码：285-295
• 全文大小：3029 K
• 卷排序：26

文摘

Aortic valve replacement is indicated in patients with severe symptomatic aortic stenosis (AS). Transcatheter aortic valve replacement (TAVR) has evolved as a potential strategy in a growing proportion of patients in preference to surgical aortic valve replacement (SAVR). This meta-analysis aims to assess the differential outcomes of TAVR and SAVR in patients enrolled in published randomised controlled trials (RCTs).MethodsA systematic literature search of Cochrane Library, EMBASE, OVID, and PubMed MEDLINE was performed. Randomised controlled trials of patients with severe AS undergoing TAVR compared with SAVR were included. Clinical outcomes and procedural complications were assessed.ResultsFive RCTs with a total of 3,828 patients (1,928 TAVR and 1,900 SAVR) were analysed. There was no statistically significant difference in combined rates of all-cause mortality and stroke at 30-days for TAVR vs SAVR (6.3% vs 7.5%; OR 0.83; 95% CI: 0.64-1.08; P = 0.17) or at 12 months (17.2% vs 19.2%; OR 0.87; 95% CI: 0.73-1.03; P = 0.29). No statistically significant difference was seen for death or stroke separately at any time point although a numerical trend in favour of TAVR for both was recorded. Length of in-patient stay was significantly less with TAVR vs SAVR (9.6 +/- 7.7 days vs 12.2 +/- 8.8 days; OR -2.94; 95% CI: -4.64 to -1.24; P = 0.0007). Major vascular complications were more frequent in patients undergoing TAVR vs SAVR (8.2% vs. 4.0%; OR 2.15; 95% CI: 1.62-2.86; P <0.00001) but major bleeding was more common among SAVR patients (20.5% vs 44.2%; OR 0.34; 95% CI: 0.22-0.52; P = <0.00001).ConclusionsTranscatheter aortic valve replacement and SAVR are associated with overall similar rates of death and stroke among patients in intermediate to high-risk cohorts but with reduced length of in-patient hospital stay.