Synaptic abnormalities of mice lacking toll-like receptor (TLR)-9
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- 作者：V. Patel ; patelv6@njms.rutgers.edu" class="auth_mail" title="E-mail the corresponding author ; A.M. Patel ; J.J. McArdle
- 关键词：ACh ; acetylcholine ; AChR ; acetylcholine receptor ; EDL ; extensor digitorum longus ; EPC ; endplate current ; HEPES-2 ; [4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid ; KO ; knock out ; m ; quantal content ; mEPC ; miniature endplate current ; NMJ ; neuromuscular junction ; PSC ; Perisynaptic Schwann cell ; SERCA2 ; sarco/endoplasmic reticulum Ca2+-ATPase 2 ; TLR ; toll-like receptor ; TS ; Triangularis sterni
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：2 June 2016
- 年：2016
- 卷：324
- 期：Complete
- 页码：1-10
- 全文大小：1509 K
文摘
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A novel role of toll-like receptor (TLR)-9 in synaptic plasticity and efficacy is proposed.
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Nerve stimulation of TLR9 KO muscles produced weaker force compared to wild type.
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NMJs, studied as a model synapse, showed pre-synaptic and post-synaptic defects in TLR9 KO mice.
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Presynaptic defects included abnormal spontaneous and evoked vesicle release.
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Endplate volume, as measured by α-bungarotoxin staining, declined.