Biomarkers for cystic fibrosis drug development

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• 作者：Marianne S. Muhlebach^a ; ¹ ; ^{marianne_muhlebach@med.unc.edu} ; JP Clancy^b ; ¹ ; Sonya L. Heltshe^c ; Assem Ziady^b ; Tom Kelley^d ; Frank Accurso^f ; Joseph Pilewski^g ; Nicole Mayer-Hamblett^c ; ^e ; Elizabeth Joseloff^h ; Scott D. Sagel^f
• 关键词：Biomarker ; Inflammation ; Microbiome ; Infection ; Advanced technologies ; Electrophysiology
• 刊名：Journal of Cystic Fibrosis
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：15
• 期：6
• 页码：714-723
• 全文大小：352 K
• 卷排序：15

文摘

To provide a review of the status of biomarkers in cystic fibrosis drug development, including regulatory definitions and considerations, a summary of biomarkers in current use with supportive data, current gaps, and future needs.MethodsBiomarkers are considered across several areas of CF drug development, including cystic fibrosis transmembrane conductance regulator modulation, infection, and inflammation.ResultsSweat chloride, nasal potential difference, and intestinal current measurements have been standardized and examined in the context of multicenter trials to quantify CFTR function. Detection and quantification of pathogenic bacteria in CF respiratory cultures (e.g.: Pseudomonas aeruginosa) are commonly used in early phase antimicrobial clinical trials, and to monitor safety of therapeutic interventions. Sputum (e.g.: neutrophil elastase, myeloperoxidase, calprotectin) and blood biomarkers (e.g.: C reactive protein, calprotectin, serum amyloid A) have had variable success in detecting response to inflammatory treatments.ConclusionsBiomarkers are used throughout the drug development process in CF, and many have been used in early phase clinical trials to provide proof of concept, detect drug bioactivity, and inform dosing for later-phase studies. Advances in the precision of current biomarkers, and the identification of new biomarkers with ‘omics-based technologies, are needed to accelerate CF drug development.