Neurovascular contributions to migraine: Moving beyond vasodilation
详细信息 查看全文
- 作者：Blaine Jacobs ; Gregory Dussor ; gregory.dussor1@utdallas.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CGRP ; calcitonin gene-related peptide ; CNP ; c-type natriuretic peptide ; CSD ; cortical spreading depression ; eNOS ; endothelial NO synthase ; ET-1 ; endothelin-1 ; MOH ; medication-overuse headache ; NO ; nitric oxide ; NTG ; nitroglycerine ; PACAP ; pituitary adenylate cyclase activating peptide ; SSN ; superior salivatory nucleus ; TNF-α ; tumor necrosis factor ; TRP ; transient receptor potential ; VEGF ; vascular endothelial cell growth factor ; VIP ; vasoactive intestinal polypeptide
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：3 December 2016
- 年：2016
- 卷：338
- 期：Complete
- 页码：130-144
- 全文大小：898 K
文摘
- •
Migraine is the 3rd most common and 8th most disabling disease on earth.
- •
Neuronal mechanisms play a key role in migraine pathophysiology.
- •
Human studies have lead to increased scrutiny of the vascular theory of migraine.
- •
Vasodilation may not be necessary or sufficient for migraine.
- •
Vascular endothelial cells may contribute to migraine without vasodilation.