The inlet manifold affects greatly the fluid flow distribution and energy consumption of the module. A novel CFD model has been developed to simulate the fluid flow in an industrial-scale hollow fiber membrane module. An adapted model has been proposed to account for the energy consumption distribution between the manifold and the fiber bundle. The velocity and pressure distributions in the shell and lumen sides have been presented as well as the three-dimensional flux distribution. Proposals have been given for better design of the module.