Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms
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- 作者：Ehab N.M. Jirgis1 ; 2 ; Ghader Bashiri1 ; 2 ; Esther M.M. Bulloch1 ; Jodie M. Johnston1 ; jm.johnston@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Edward N. Baker1 ; ted.baker@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author
- 关键词：thiamin diphosphate ; MenD ; menaquinone biosynthesis ; reaction intermediates ; crystal structures
- 刊名：Structure
- 出版年：2016
- 出版时间：6 July 2016
- 年：2016
- 卷：24
- 期：7
- 页码：1167-1177
- 全文大小：3200 K
文摘
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A series of crystal structures presented for MenD from Mycobacterium tuberculosis
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These structures track the catalytic cycle of MenD through each reaction stage
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Reaction intermediates reveal conformational features crucial to each step
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Asymmetry between paired active sites indicates alternating site reactivity
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