Genetically different pig breeds exhibited a differential host susceptibility to HP-PRRSV.
Tibetan pig was much less susceptible to HP-PRRSV in the three tested pig breeds.
The reduced susceptibility of ZangMei pig to PRRSV may be contributed by the genome of Tibetan pig.
Study on host susceptibility of Tibetan pig to PRRSV may display the mechanism of pig resistance to PRRS disease.