3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012
详细信息 查看全文
- 作者：Reed F. Johnsona ; johnsonreed@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Ulas Bagcib ; h ; Lauren Keithc ; Xianchun Tangd ; Daniel J. Mollurab ; Larry Zeitline ; Jing Qinf ; Louis Huzellac ; Christopher J. Bartosc ; Natasha Bohorovae ; Ognian Bohorove ; Charles Goodmane ; Do H. Kime ; Michael H. Paultye ; Jesus Velascoe ; Kevin J. Whaleye ; Joshua C. Johnsonc ; James Pettittc ; Britini L. Orkc ; Jeffrey Solomoni ; Nicholas Oberlanderc ; Quan Zhud ; Jiusong Sund ; Michael R. Holbrookc ; Gene G. Olingerc ; Ralph S. Baricg ; Lisa E. Hensleyc ; Peter B. Jahrlinga ; c ; Wayne A. Marascod
- 关键词：MERS-CoV ; Antibody therapy ; Animal model ; MERS ; Respiratory syndrome ; Human monoclonal antibody therapy
- 刊名：Virology
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：490
- 期：Complete
- 页码：49-58
- 全文大小：3486 K
文摘
- •
MERS-CoV Jordan-n3/2012 challenge of rhesus monkeys results in a mild disease.
- •
CT can be used to monitor disease progression to aid models of human disease.
- •
Treatment with the human monoclonal antibody 3B11-N resulted in decreased disease.