Metabolomics and Metabolic Diseases: Where Do We Stand?

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• 作者：Christopher B. Newgard¹ ; ² ; ^{chris.newgard@duke.edu}
• 关键词：metabolomics ; diabetes ; metabolism ; metabolic diseases ; obesity ; cardiovascular diseases
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：43-56
• 全文大小：1537 K
• 卷排序：25

文摘

Metabolomics, or the comprehensive profiling of small molecule metabolites in cells, tissues, or whole organisms, has undergone a rapid technological evolution in the past two decades. These advances have led to the application of metabolomics to defining predictive biomarkers for incident cardiometabolic diseases and, increasingly, as a blueprint for understanding those diseases’ pathophysiologic mechanisms. Progress in this area and challenges for the future are reviewed here.