ROS/oxidative stress signaling in osteoarthritis
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- 作者：Panagiotis Lepetsosa ; Athanasios G. Papavassilioub ; papavas@med.uoa.gr" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADAMTS ; a disintegrin and metalloproteinase with thrombospondin motifs ; ATF/CRE ; activating transcription factor/cyclic AMP-response element ; ATF-2 ; activating transcription factor 2 ; Bach 1 ; broad complex-tramtrack-bric-a-brac (BTB) and cap'n'collar (CNC) homology 1 ; BAX ; Bcl-2-associated X protein ; Bcl-2 ; B-cell lymphoma 2 ; CAT ; catalase ; CASP ; caspase ; COL ; collagen ; COX-2 ; cyclooxygenase 2 ; CREB-1 ; cAMP responsive element-binding protein 1 ; ECM ; extracellular matrix ; FOXO ; forkhead-box class
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1862
- 期：4
- 页码：576-591
- 全文大小：1167 K
文摘
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Osteoarthritis (OA) is a whole-joint degenerative multifactorial disease.
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OA pathogenesis is influenced by oxidative stress, aging, hormones, and lifestyle habits.
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Disease-modifying regimens are yet not available for OA.
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Understanding OA pathobiology should lead to the discovery of more effective treatments.
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Unraveling deregulated signaling cascades in OA will aid the development of novel therapies.