The role of matrix metalloproteinases in muscle and adipose tissue development and meat quality: A review

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• 作者：Sara Christensen ; Peter P. Purslow ; ^{ppurslow@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Matrix metalloprotease ; MMP ; TIMP ; Meat ; Connective tissue ; IMF ; Adipogenesis ; Development ; Muscle growth ; Meat toughness
• 刊名：Meat Science
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：119
• 期：Complete
• 页码：138-146
• 全文大小：1120 K

文摘

Matrix metalloproteinases (MMPs) are a group of enzymes that degrade extracellular matrix components but are also important signaling molecules that regulate many biological processes including muscle, adipose and connective tissue development. Most recently it has been discovered that MMPs act as intracellular signaling molecules inducing gene expression and altering related proteins in the nucleus. Several single nucleotide polymorphisms of MMPs and their inhibitors are known to exist and most of the research on MMPs to date has focused on their activity in relation to human health and disease. Nevertheless there is a growing body of evidence identifying important roles of MMPs as regulators of myogenesis, fibrogenesis and adipogenesis. The aim of this review is to highlight the currently known functions of the MMPs that have a direct bearing on the deposition of meat components and their relationship with meat quality. Some central pathways by which these enzymes can affect the tenderness, the amount and type of fatty acids are highlighted.