RNAi of Mad, Smox and Medea unveils their functions in Blattella metamorphosis.
Mad and Medea regulate adult ecdysis and wing extension.
The effects on wing extension are mediated by bursicon.
Smox and Medea regulate adult molting timing and co-activate E93 expression.
TGF-β signaling adds robustness to the MEKRE93 pathway that regulates metamorphosis.