Heterocyclic aromatic amines and their contribution to the bacterial mutagenicity of the particulate phase of cigarette smoke
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- 作者：Ewald Roemera ; Thomas Meisgenb ; Joerg Diekmannb ; Lynda Conroyb ; Regina Stabberta ; regina.stabbert@pmi.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AαC ; 2-amino-9H-pyrido[2 ; 3-b]indole (amino-α-carbolin) ; CI ; chemical ionization ; CS ; cigarette smoke ; DMSO ; dimethyl sulfoxide ; GC&ndash ; MS/MS ; gas chromatography tandem mass spectrometry ; Glu-P-1 ; 2-amino-6-methyldipyrido[1 ; 2-α ; 3&prime ; 2&prime ; -d]imidazole ; Glu-P-2 ; 2-aminodipyrido[1 ; 2-α ; 3&prime ; 2&prime ; -d]imidazole ; ISO ; International Organization for Standardization ; IQ ; 2-amino-3-methylimidazo[4 ; 5-f]quinolone ; MeAαC ; 2-amino-3-methyl-9H-pyrido[2 ; 3-b]indole (methylamino-α-carbolin) ; MelQ ; 2
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：22 January 2016
- 年：2016
- 卷：243
- 期：Complete
- 页码：40-47
- 全文大小：862 K
文摘
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A method for the quantification of 8 heterocyclic aromatic amines (HAAs) in cigarette smoke (CS) is reported.
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The mutagenic potency of these 8 HAAs and that of CS was determined in the Salmonella Reverse Mutation Assay.
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The 8 HAAs do not contribute significantly to the bacterial in vitro mutagenicity of CS.