Epigenetic regulation of active Chinese herbal components for cancer prevention and treatment: A follow-up review

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• 作者：Zhiying Huang^a ; Qiuju Huang^a ; Liyan Ji^a ; Ying Wang^a ; Xiaoxiao Qi^a ; Liang Liu^b ; Zhongqiu Liu^a ; ^b ; ^{liuzq@gzucm.edu.cn} ; Linlin Lu^a ; ^b ; ^{lllu@gzucm.edu.cn}
• 关键词：DNMT ; DNA methyltransferase ; HMT ; histone methytransferase ; HDMT ; histone demethylase ; HAT ; histone acetylatransferase ; HDAC ; histone deacetylase ; MBP ; methy-CpG binding protein ; DMAP1 ; DNMT1-associated protein ; MBD ; methy-CpG binding domain ; FDA ; Food and Drug Administration ; CGIs ; CpG islands ; KMT ; histone lysine methyltransferase ; KDMT ; histone lysine demethylase ; SUV ; suppressor of variegation ; EZH ; enhancer of zeste proteins ; Trx ; trithorax ; LSD1 ; lysine specific demethylase 1 ; JmjC ; jumonj
• 刊名：Pharmacological Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：114
• 期：Complete
• 页码：1-12
• 全文大小：3172 K
• 卷排序：114

文摘

Epigenetic modifications include DNA methylation, histone modification, and other patterns. These processes are associated with carcinogenesis and cancer progression. Thus, epigenetic modification-related enzymes, such as DNA methyltransferases (DNMTs), histone methyltransferases (HMTs), histone demethylases (HDMTs), histone acetyltransferases (HATs), and histone deacetylases (HDACs), as well as some related proteins, including methyl-CpG binding proteins (MBPs) and DNMT1-associated protein (DMAP 1), are considered as potential targets for cancer prevention and therapy. Numerous natural compounds, mainly derived from Chinese herbs and chemically ranging from polyphenols and flavonoids to mineral salts, inhibit the growth and development of various cancers by targeting multiple genetic and epigenetic alterations. This review summarizes the epigenetic mechanisms by which active compounds from Chinese herbs exert their anti-cancer effect. A subset of these compounds, such as curcumin and resveratrol, affect multiple epigenetic processes, including DNMT inhibition, HDAC inactivation, MBP suppression, HAT activation, and microRNA modulation. Other compounds also regulate epigenetic modification processes, but the underlying mechanisms and clear targets remain unknown. Accordingly, further studies are required.