In vivo and in silico studies to identify mechanisms associated with Nurr1 modulation following early life exposure to permethrin in rats

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• 作者：Donatella Fedeli^a ; ^&dagger ; ; Maura Montani^b ; ^&dagger ; ; Laura Bordoni^c ; Roberta Galeazzi^d ; Cinzia Nasuti^a ; Luí ; sa Correia-Sá ; ^e ; Valentina F. Domingues^e ; Maini Jayant^f ; Vani Brahmachari^f ; Luca Massaccesi^d ; Emiliano Laudadio^d ; Rosita Gabbianelli^a ; ^{rosita.gabbianelli@unicam.it}
• 关键词：3-PBA ; 3-phenoxybenzoic acid ; BBB ; blood&ndash ; brain barrier ; DNMTs ; DNA methyltransferases ; EDTA ; ethylenediaminetetraacetic acid ; LBD ; Ligand Binding Domain ; MSP ; Methylation-Specific PCR ; NOAEL ; No Observed Adverse Effect Level ; NuIP ; Nurr1-interacting protein ; PBS ; phosphate buffered saline ; PBS-T ; PBS containing 0.05% Tween 20 ; PD ; Parkinson&rsquo ; s disease ; PERM ; permethrin ; TH ; tyrosine hydroxylase
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：6 January 2017
• 年：2017
• 卷：340
• 期：Complete
• 页码：411-423
• 全文大小：2390 K
• 卷排序：340

文摘

Permethrin crosses the blood–brain barrier. Early life permethrin treatment modifies DNMTs. Monomeric and aggregated α-synuclein levels increase in adolescent rats. No change in Nurr1 promoter methylation was measured.