METTL3 Gains R/W Access to the Epitranscriptome

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• 作者：Ulrike Schumann¹ ; Andrew Shafik¹ ; Thomas Preiss¹ ; ² ; ³ ; ^{thomas.preiss@anu.edu.au" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Molecular Cell
• 出版年：2016
• 出版时间：5 May 2016
• 年：2016
• 卷：62
• 期：3
• 页码：323-324
• 全文大小：222 K

文摘

Epitranscriptomic marks are dynamically placed on mRNA by “writer” or “eraser” enzymes, while “readers” modulate their function accordingly. Lin et al. (2016) now report that the N6-methyladenosine:RNA methyltransferase METTL3 is both a writer and a reader, directly enhancing mRNA translation.