Treating psoriasis by targeting its susceptibility gene Rel
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- 作者：Tingting Fana ; Shaowen Wanga ; Linjiang Yua ; Huqiang Yib ; Ruiling Liua ; Wenwen Genga ; Xiaochun Wana ; Yifan Maa ; Lintao Caib ; Youhai H. Chenc ; Qingguo Ruana ; qg.ruan@siat.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：c-Rel ; Psoriasis ; IL-17A ; siRNA ; PEG-PLL-PLLeu micelles
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：165
- 期：Complete
- 页码：47-54
- 全文大小：1097 K
文摘
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Nanoparticle-loaded siRNA accumulated in lymphoid organs.
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c-Rel-specific siRNA can be used to prevent & treat imiquimod induced psoriasis.
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c-Rel-specific siRNA down-regulates the expression of inflammatory cytokines.
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c-Rel may be a potential therapeutic target for psoriasis prevention & treatment.