Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation
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- 作者：Benjamin E. Blass ; Keith Coburn ; Wenlin Lee ; Neil Fairweather ; Andrew Fluxe ; Shengde Wu ; John M. Janusz ; Michael Murawsky ; Gina M. Fadayel ; Bin Fang et al.
- 关键词：Atrial fibrillation ; Kv1.5 ion channel ; 1 ; 2 ; 3-Triazole
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2006
- 出版时间：1 September 2006
- 年：2006
- 卷：16
- 期：17
- 页码：4629-4632
- 全文大小：172 K
文摘
A series of novel (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones were prepared and examined for utility as Kv1.5 channel blockers for the treatment of atrial fibrillation.