Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer

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• 作者：Milica Momcilovic¹ ; ¹⁰ ; Sean T. Bailey¹ ; ¹⁰ ; Jason T. Lee³ ; Michael C. Fishbein² ; Clara Magyar² ; Daniel Braas³ ; ⁶ ; Thomas Graeber³ ; ⁵ ; ⁶ ; Nicholas J. Jackson⁷ ; Johannes Czernin³ ; ⁵ ; Ethan Emberley⁹ ; Matthew Gross⁹ ; Julie Janes⁹ ; Andy Mackinnon⁹ ; Alison Pan⁹ ; Mirna Rodriguez⁹ ; Melissa Works⁹ ; Winter Zhang⁹ ; Francesco Parlati⁹ ; Susan Demo⁹ ; Edward Garon⁴ ; ⁵ ; Kostyantyn Krysan¹ ; Tonya C. Walser¹ ; Steven M. Dubinett¹ ; ² ; ⁵ ; Saman Sadeghi³ ; Heather R. Christofk³ ; ⁵ ; ⁶ ; ⁸ ; David B. Shackelford¹ ; ⁵ ; ¹¹ ; ^{dshackelford@mednet.ucla.edu}
• 关键词：EGFR ; lung cancer ; glutamine ; erlotinib ; CB-839 ; PET imaging ; AMPK ; metabolic crisis
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：18
• 期：3
• 页码：601-610
• 全文大小：3642 K
• 卷排序：18

文摘

Targeted EGFR and GLS inhibition cooperate in vivo to induce rapid tumor regression Measured metabolic response to EGFR and GLS inhibitors using 18F-FDG and 11C-Gln PET EGFR and GLS inhibition induce severe energetic stress and cell death in lung tumors