Approaches for describing and communicating overall uncertainty in toxicity characterizations: U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) as a case study
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- 作者：Nancy B. Becka ; nancy_beck@americanchemistry.com" class="auth_mail" title="E-mail the corresponding author ; Richard A. Beckera ; rick_becker@americanchemistry.com" class="auth_mail" title="E-mail the corresponding author ; Neeraja Erraguntlab ; 1 ; Neeraja_Erraguntla@americanchemistry.com" class="auth_mail" title="E-mail the corresponding author ; William H. Farlandc ; William.Farland@ColoState.edu" class="auth_mail" title="E-mail the corresponding author ; Roberta L. Grantb ; 2 ; robertagrant1357@gmail.com" class="auth_mail" title="E-mail the corresponding author ; George Grayd ; gmgray@gwu.edu" class="auth_mail" title="E-mail the corresponding author ; Christopher Kirmane ; ckirman@summittoxicology.com" class="auth_mail" title="E-mail the corresponding author ; Judy S. LaKindf ; g ; h ; lakindassoc@gmail.com" class="auth_mail" title="E-mail the corresponding author ; R. Jeffrey Lewisi ; r.jeffrey.lewis@exxonmobil.com" class="auth_mail" title="E-mail the corresponding author ; Patricia Nancej ; patricia.nance@uc.edu" class="auth_mail" title="E-mail the corresponding author ; Lynn H. Pottengerk ; 3 ; Susan L. Santosl ; ssantos.focusgroup@comcast.net" class="auth_mail" title="E-mail the corresponding author ; Stephanie Shirleyb ; stephanieharkeyshirley@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ted Simonm ; ted@tedsimon-toxicology.com" class="auth_mail" title="E-mail the corresponding author ; Michael L. Doursonj ; michael.dourson@uc.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Environment International
- 出版年：2016
- 出版时间：April-May 2016
- 年：2016
- 卷：89-90
- 期：Complete
- 页码：110-128
- 全文大小：2673 K
文摘
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Five approaches are shown to transparently present toxicity value information.
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The approaches should increase transparency and understanding.
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These graphical/tabular approaches also improve characterization of uncertainty.
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Visualization of assumptions helps to contextualize accuracy of point estimates.
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Use and empirical testing will help determine best approaches and best practices.