Brincidofovir for Asymptomatic Adenovirus Viremia in Pediatric and Adult Allogeneic Hematopoietic Cell Transplant Recipients: A Randomized Placebo-Controlled Phase II Trial

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• 作者：Michael S. Grimley¹ ; ^{michael.grimley@cchmc.org} ; Roy F. Chemaly² ; Janet A. Englund³ ; Joanne Kurtzberg⁴ ; Gregory Chittick⁵ ; Thomas M. Brundage⁵ ; Andrew Bae⁵ ; Marion E. Morrison⁵ ; Vinod K. Prasad⁴
• 关键词：Adenoviruses ; Brincidofovir ; BCV ; CMX001 ; Antiviral ; Stem cell transplantation ; Treatment
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：23
• 期：3
• 页码：512-521
• 全文大小：1211 K
• 卷排序：23

文摘

There is an unmet need for effective therapy for adenovirus infection in hematopoietic cell transplant recipients Brincidofovir has potent antiviral activity against adenovirus in vitro Rapid decreases in adenovirus viremia were observed after initiation of brincidofovir twice weekly Early intervention with brincidofovir may provide clinical benefit in adenovirus viremia